Imoto D, Yamamoto I, Matsunaga H, Yonekura T, Lee ML, Kato KX, Yamasaki T, Xu S, Ishimoto T, Yamagata S, Otsuguro KI, Horiuchi M, Iijima N, Kimura K, Toda C.
Refeeding activates neurons in the dorsomedial hypothalamus to inhibit food intake and promote positive valence.
Mol Metab. 2021 Dec;54:101366. doi: 10.1016/j.molmet.2021.101366.
Lee ML, Matsunaga H, Sugiura Y, Hayasaka T, Yamamoto I, Ishimoto T, Imoto D, Suematsu M, Iijima N, Kimura K, Diano S, Toda C.
Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism.
Nat Commun. 2021 Apr 20;12(1):2330. doi: 10.1038/s41467-021-22431-6.
Toda C, Kim JD, Impellizzeri D, Cuzzocrea S, Liu ZW, Diano S.
UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness.
Cell. 2016 Feb 25;164(5):872-83. doi: 10.1016/j.cell.2016.02.010.
2022
Hashimoto M, Fujimoto M, Konno K, Lee ML, Yamada Y, Yamashita K, Toda C, Tomura M, Watanabe M, Inanami O, Kitamura H.
USP2 in the ventromedial hypothalamus modifies blood glucose levels by controlling sympathetic nervous activation.
J Neurosci. 2022 Apr 26:JN-RM-2504-21. doi: 10.1523/JNEUROSCI.2504-21.2022.
Jeong JK, Ruan HB, Toda C.
Editorial: Crosstalk Between the Metabolic and Cardiovascular Systems in the Brain.
Front Physiol. 2022 Jan 27;12:834637. doi: 10.3389/fphys.2021.834637.
2021
Imoto D, Yamamoto I, Matsunaga H, Yonekura T, Lee ML, Kato KX, Yamasaki T, Xu S, Ishimoto T, Yamagata S, Otsuguro KI, Horiuchi M, Iijima N, Kimura K, Toda C.
Refeeding activates neurons in the dorsomedial hypothalamus to inhibit food intake and promote positive valence.
Mol Metab. 2021 Dec;54:101366. doi: 10.1016/j.molmet.2021.101366.
Lee ML, Matsunaga H, Sugiura Y, Hayasaka T, Yamamoto I, Ishimoto T, Imoto D, Suematsu M, Iijima N, Kimura K, Diano S, Toda C.
Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism.
Nat Commun. 2021 Apr 20;12(1):2330. doi: 10.1038/s41467-021-22431-6.
2020以前
Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y*.
Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.
Cell Reports. 22:706-721, 2018
Shiuchi T, Toda C, Okamoto S, Coutinho EA, Saito K, Miura S, Ezaki O, Minokoshi Y*.
Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK.
Scientific Reports. 7:15141, 2017
Saito N, Kimura S, Miyamoto T, Fukushima S, Amagasa M, Shimamoto Y, Nishioka C, Okamoto S, Toda C, Washio K, Asano A, Miyoshi I, Takahashi E, Kitamura H*.
Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice.
Biochem Biophys Rep. 9:322-329, 2017
Kim JD, Toda C, Ramírez CM, Fernández-Hernando C, Diano S*.
Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity.
Diabetes. 2017 66:2102-2111, 2017
Toda C, Kim JD, Impellizzeri D, Cuzzocrea S, Liu ZW, Diano S*.
UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness.
Cell. 64:872-883, 2016
Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T*.
Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.
Scientific Reports, 5:17565, 2015
Tang L, Okamoto S, Shiuchi T, Toda C, Takagi K, Sato T, Saito K, Yokota S, Minokoshi Y*.
Sympathetic Nerve Activity Maintains an Anti-Inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages.
Endocrinology, 156:3680-3694, 2015
Long L, Toda C, Jeong JK, Horvath TL, Diano S*.
PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding.
Journal of Clinical Investigation, 124:4017-4027, 2014
Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S*.
Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice.
Proceedings of the National Academy of Sciences, 111:11876-11881, 2014
Toda C, Shiuchi T, Kageyama H, Okamoto S, Coutinho EA, Sato T, Okamatsu-Ogura Y, Yokota S, Takagi K, Tang L, Saito K, Shioda S, Minokoshi Y*.
Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle.
Diabetes. 62:2295-2307, 2013
Kitamura H*, Kimura S, Shimamoto Y, Okabe J, Ito M, Miyamoto T, Naoe Y, Kikuguchi C, Meek B, Toda C, Okamoto S, Kanehira K, Hase K, Watarai H, Ishizuka M, El-Osta A, Ohara O, Miyoshi I.
Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation.
FASEB J. 27:4940-4953, 2013
Tanaka M, Suganami T, Kim-Saijo M, Toda C, Tsuiji M, Ochi K, Kamei Y, Minokoshi Y, Ogawa Y*.
Role of central leptin signaling in the starvation-induced alteration of B-cell development.
Journal of Neuroscience 31:8373-8380. 2011
Saito K, Lee S, Shiuchi T, Toda C, Kamijo M, Inagaki-Ohara K, Okamoto S, Minokoshi Y*.
An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes.
Analytical Biochemistry 412:9-17, 2011
Toda C, Shiuchi T, Lee S, Yamato-Esaki M, Fujino Y, Suzuki A, Okamoto S, Minokoshi Y*.
Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues.
Diabetes. 58:2757-2765, 2009
Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y*.
Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system.
Cell Metabolism 10:466-480, 2009
Okamatsu-Ogura Y, Uozumi A, Toda C, Kimura K, Yamashita H, Saito M*.
Uncoupling protein 1 contributes to fat-reducing effect of leptin.
Obes Res Clin Pract. 1:223-290, 2007
Omachi A, Ishioka K, Uozumi A, Kamikawa A, Toda C, Kimura K, Saito M*.
Beta3-adrenoceptor agonist AJ-9677 reduces body fat in obese beagles.
Res Vet Sci. 83:5-11, 2007
Inokuma K, Ogura-Okamatsu Y, Toda C, Kimura K, Yamashita H, Saito M*.
Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue.
Diabetes. 54:1385-1391, 2005